Dissecting the role of glial lipids in neurodegeneration

Lipidomics and metabolomics analyses to identify disease-specific states of astrocytes and microglia in Alzheimer's disease and neuroinflammation.

Profiling reactive astrocyte subtypes at the molecular level

Characterizing the protein profiles of reactive astrocyte subtypes including interferon-responsive reactive astrocytes and neurotoxic reactive astrocytes.

Development of biochemical tools to investigate glial function

Development of biochemical tools to evaluate how glia respond to the pathogenic Aβ peptide associated with Alzheimer's disease.